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Nembutal sodium pentobarbital is a short-acting barbiturate, chemically designated as sodium 5-ethyl-5-(1-methylbutyl) barbiturate. This is one of the reasons for being more suitable for suicide than longer-acting barbiturates such as phenobarbital.
Nembutal sodium pentobarbital is also used short-term as a sedative to treat insomnia, or to cause you to fall asleep for surgery. This medicine is also used as an emergency treatment for seizures.
Forms of Medication
Pentobarbital is available in the following forms:
Nembutal is a proven, reliable drug that brings about a peaceful death. Almost no failures are known, despite large statistics (for example, the Swiss euthanasia organisation Dignitas reported 840 exits with no single failure). There are however reports on seemingly slow or painful deaths with Nembutal in capital punishment, although this may be due to poor quality of the drug from compounding pharmacies given intravenously rather than orally.
Nembutal sodium pentobarbital is sold most of the time in liquid form for use as a sedative and anesthetic in hospitals. veterinary Nembutal is a liquid and not in pill-form, which means that it has a shorter shelf life. On the other hand, Seconal (secobarbital), a short acting barbiturate that is as powerful as Nembutal if not more powerful, is still available in capsule form in the USA, EUROPE and probably the UK. Nembutal pills has a bitter taste that require the use of antiemetics to prevent vomiting when given orally at high dosages.
It is easy from today form today to obtain vials of Nembutal Sodium Solution (pentobarbital sodium injection), a sterile solution for intravenous or intramuscular injection, typically used for animal anaesthesia or euthanasia. Each mL contains pentobarbital sodium 50 mg ,100 mg or 250 mg (lethal dose), capsules and suppositories in a vehicle of approximately propylene glycol, 40%, alcohol, 10% and water for injection, to volume. The pH is adjusted to approximately 9.5 with hydrochloric acid and/or sodium hydroxide. The range of actual pentobarbital sodium in a vial may vary between 3 g to 15 g, although 6 g seems common. The containers come in a clear vial typical for sterile solutions, and should have an untouched protective metal cap if unopened, and be labelled clearly with due date. The nembutal solution may be taken intravenously, for very quick effect as in capital punishment, or orally.
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You should not use this medicine if you have a history of porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).
Before taking this medicine
You should not use this medicine if you are allergic to Nembutal Sodium or other barbiturates (butabarbital, phenobarbital, Luminal, Seconal, and others), or if you have:
a history of porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).
To make sure Nembutal sodium pentobarbital is safe for you, tell your doctor if you have:
liver disease, kidney disease; temporary or chronic pain;
a history of addiction to phenobarbital or similar medicines (Valium, Xanax, Ativan, and others).
Using Nembutal sodium pentobarbital during pregnancy could harm the unborn baby. If you use this medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.
Nembutal Sodium can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.
Sedatives used during surgery may affect brain development in a child under 3, or an unborn baby whose mother receives this medicine during late pregnancy. These effects may be more likely when the medicine is used for 3 hours or longer, or used for repeated procedures. Effects on brain development could cause learning or behavior problems later in life.
Negative brain effects from anesthesia have been seen in animal studies. However, studies in human children receiving single short uses of anesthesia have not shown a likely effect on behavior or learning. More research is needed.
In some cases, your doctor may decide to postpone a surgery based on these risks. Treatment may not be delayed in the case of life-threatening conditions, medical emergencies, or surgery needed to correct certain birth defects.
Ask your doctor for information about all medicines that will be used during your surgery, and how long the surgery will last.
Pentobarbital can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breastfeeding a baby.
How is Nembutal Sodium given?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Nembutal Sodium may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it
Nembutal Sodium is injected into a muscle, or into a vein through an IV or by drinking (pills, powder)
You may be shown how to use Nembutal Sodium at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.
Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely after you receive Nembutal Sodium in a hospital setting.
If you use this medicine long-term, you may need frequent medical tests.
Do not stop using this medicine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using Nembutal Sodium.
Store at room temperature away from moisture and heat. Do not freeze.
What happens if I miss a dose?
Since Nembutal Sodium is often used only when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
Potentiating the cocktail and masking the taste
It is usually recommended to drink some alcohol immediately after (not prior) to the Nembutal ingestion to potentiate its effect and mask the very bitter taste.
Eating a big meal prior to or after the drug ingestion is not recommended to reduce chances of slow drug absorption or vomiting. Dignitas offers clients chocolates to deal with the bitter taste of the drug.
Time To Death
Experience in the world has learned that after ingesting 50 grams of either or lethal dose pentobarbital or secobarbital, death generally occurs within two hours maximum
A pentobarbital overdose is an amount taken in excess of that which is medically recommended. Two to ten grams excess can cause death
In extreme overdose, all electrical activity in the brain may cease, in which case a “flat” EEG normally equated with clinical death cannot be accepted. This effect is fully reversible unless hypoxic damage occurs. Consideration should be given to the possibility of barbiturate intoxication even in situations that appear to involve trauma.